European shares hit their highest in nearly four months on Friday, helped by gains in Bayer after an asset sale deal paving the way for the German drugmaker's $66-billion acquisition of Monsanto.

The pan-European STOXX 600 rose 0.3 per cent, also underpinned by strength among materials stocks. The index was set for its fifth straight week of gains as inflows into equities continued, with confidence over an economic recovery outweighing rumblings of political risk.

Germany's DAX index was flat, just below the all-time high hit in the previous session, while Britain's FTSE eased back 0.3 per cent after a record close on Thursday.

According to EPFR Global data, European equity funds posted solid weekly inflows overall. But Spanish funds suffered their second largest outflow on record and redemptions from Italy climbed to levels last seen in the second quarter of 2015.

Spain's IBEX has lagged over the past two weeks amid concerns over the country's future following an independence referendum in the region of Catalonia declared illegal by authorities in Madrid.

Italy's FTSE MIB has been hit by a sell-off in its banks on worries regulators could impose stricter provisioning rules on bad loans.

On Friday, Bayer gave the biggest boost to the STOXX 600, up 1.6 per cent after BASF, the world's third-largest maker of crop chemicals, agreed to buy significant parts of its seed and herbicide businesses for 5.9 billion euros in cash. BASF fell 0.7 per cent.

Bayer said it would use the proceeds of the sale to partially refinance the planned acquisition of Monsanto, which it hopes will close in early 2018.

“The recent divestments together with a potential radiology divestment could mean that Bayer only needs a capital raise of below $10 billion which would be a positive surprise,” said Baader Helvea analyst Markus Mayer in a note.

Analysts, including Mayer, said the price paid by BASF was higher than expected but terms of the deal were more favourable compared to market valuation multiples in the same sector.

Bayer is up 19 per cent so far this year, against a flat performance for BASF and a 13 per cent rise for the DAX. ACS rose 0.7 per cent after sources told Reuters the Spanish builder would launch next week a cash-and-share offer for toll road operator Abertis, complicating a rival bid by Italy's Atlantia.

The offer was expected to be roughly half in cash and the rest in newly issued shares in German construction group Hochtief, which is controlled by ACS, the sources said.

Abertis and Atlantia were flat while Hochtief fell 0.9 per cent.

Among top STOXX 600 gainers were Provident Financial , up 18 per cent at a six week high. The British subprime lender put in place a recovery plan for its home credit business which it said was set to post a 2017 loss of up to 120 million pounds.

A well-received earnings update boosted shares in Man Group , up 2.8 per cent. The British hedge fund said assets rose 7.9 per cent in the third quarter, boosted by market gains and net inflows to its funds.

Top faller was British engineering group GKN which fell 6.4 per cent after a profit warning. The company said full-year profit would come in lower than expected due to disappointing trading in aerospace and two external claims that were expected to cost 40 million pounds.

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