Wall Street had ended little changed on Thursday after a moderate late-day rally as media stocks, which slumped on negative business updates from Walt Disney and Comcast, were offset by gains in healthcare shares.

Comcast dropped 6.2 per cent after the cable operator warned of subscriber losses, while Disney shares fell 4.4 per cent after the company cautioned about its profit growth. The S&P 500 media index ended down 3.6 per cent.

Gains in healthcare stocks such as AbbVie and Bristol-Myers Squibb buoyed indexes, while strength in Microsoft and Amazon helped keep the tech-heavy Nasdaq in positive territory.

Hurricane Irma

Investors were tracking Hurricane Irma, which was bearing down on Florida on the heels of devastation in Texas caused by Hurricane Harvey. Irma plowed past the Dominican Republic toward Haiti after devastating a string of Caribbean islands.

With Irma looming, shares of insurers were weaker, with the Dow Jones US Insurance index off 1.9 per cent.

Theres further uncertainty because of Hurricane Irma that is supposed to be hitting Florida. You dont know what kind of damage it is going to do,” said John Praveen, managing director at Prudential International Investments Advisers in Newark, New Jersey.

Combined with Harvey, in the short term, Praveen said, "maybe it will have a negative impact upon US GDP growth and it might hurt US earnings, and thats probably why the markets are reacting negatively.”

The Dow Jones Industrial Average fell 22.86 points, or 0.1 per cent, to 21,784.78, the S&P 500 lost 0.44 points, or 0.02 per cent, to 2,465.1 and the Nasdaq Composite added 4.56 points, or 0.07 per cent, to 6,397.87.

Irma is the latest macro event to keep pressure on US equities following concerns earlier this week about geopolitical tensions involving North Korea, which sparked the biggest one-day drop for the S&P 500 in about three weeks. Adding to concerns, September historically has been the worst month for stocks, according to the Stock Trader's Almanac.

Still, the benchmark S&P remains near all-time highs, with market watchers pointing to strong earnings growth and solid economic data as helping to support stocks.

For being in such a nervous world right now, the market has done exceptionally well, said Peter Tuz, president of Chase Investment Counsel in Charlottesville, Virginia.

ECB stimulus programme

Investors were also digesting comments from European Central Bank President Mario Draghi, who said the euro's strength was already weighing on inflation and will be a key factor for the ECB next month when it decides how to proceed with its massive stimulus programme.

General Electric shares sank 3.6 per cent, dragging on the S&P and the Dow, after a bearish analyst note.

Apple shares also weighed on major indexes, falling 0.4 per cent after a report that the company's new iPhone was hit with production glitches. Financial shares slid 1.7 per cent amid a drop in US Treasury yields.

Healthcare was the best-performing sector, rising 1.1 per cent. AbbVie shares surged 6.1 per cent and Bristol-Myers Squibb gained 5.0 per cent after the drugmakers separately reported positive developments for their respective medicines. Eli Lilly shares rose 1.3 percent after it said it would lay off about 8 per cent of its employees.

Advancing issues outnumbered declining ones on the NYSE by a 1.07-to-1 ratio; on Nasdaq, a 1.06-to-1 ratio favoured decliners. About 6.4 billion shares changed hands on US exchanges, above the 5.8 billion daily average over the last 20 sessions.

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